Exercise Ventilatory Limitation

Ventilatory mechanics and expiratory flow limitation during exercise in normal subjects.

We have examined the interrelationships among transpulmonary pressure, flow, and volume during exhausting exercise in 10 normal adult males. Expiratory transpulmonary pressures during exercise were compared with flow-limiting pressures measured at rest by two techniques. In no case did pressures developed during exercise exceed to an appreciable extent the flow-limiting pressures. This indicate...

Assessing Exercise Limitation Using Cardiopulmonary Exercise Testing

The cardiopulmonary exercise test (CPET) is an important physiological investigation that can aid clinicians in their evaluation of exercise intolerance and dyspnea. Maximal oxygen consumption ([Formula: see text]) is the gold-standard measure of aerobic fitness and is determined by the variables that define oxygen delivery in the Fick equation ([Formula: see text] = cardiac output × arterial-v...

Exercise Limitation following Extensive Pulmonary Resection.

Exercise limitation in patients with polymyositis.

To examine the hypothesis that patients with inflammatory muscle disease have impairments in cardiac and/or pulmonary function that are masked by peripheral muscle weakness, complete PFTs, echo/Doppler studies and exercise testing were performed in 11 patients with polymyositis. Maximal inspiratory and expiratory pressures and expiratory flow rates were normal. One patient had evidence of restr...

Leptin and the ventilatory response to exercise in heart failure.

OBJECTIVES The aim of the study was to test the hypothesis that leptin is involved in the regulation of ventilatory responses to exercise in chronic heart failure (CHF). BACKGROUND Exercise-induced hyperventilation is a negative prognostic factor in CHF. Studies in animals suggest that leptin, a hormone secreted by adipocytes, contributes to the regulation of respiration. Plasma leptin levels...